Peptide Synthesis and UBL Technology

Chemical peptide synthesis technology has evolved considerably in the past few years. Nevertheless, the UBL fusion system offers distinct advantages over chemical synthesis, as highlighted in the table. It is possible to design the peptide gene very rapidly, and to express and purify the peptide in ten days. The peptide can be labeled with stable isotope according to various protocols. Peptide yield is enhanced greatly by UBL fusion, and the scale up cost of the recombinant peptide is lower than the cost of chemical synthesis. In addition, some peptides that cannot be synthesized in biologically active form are easily made as active UBL-fusions and purified with great facility after cleavage of the UBL.

* An average of figures taken from five custom peptide synthesis companies