Human Ubiquitin

Ubiquitin, as the name suggests is a highly ubiquitous protein present in all eukaryotes. It is absent from prokaryotes. Ubiquitin, a 76 amino acid residue protein, is the most highly conserved protein known thus far. Highly purified forms of human ubiquitin by VLI Research are extremely stable under a variety of conditions.

The NMR structure of ubiquitin was discovered in the mid 1980's. For a small protein, ubiquitin is endowed with a rich secondary and tertiary structure, three and a half alpha helices, five beta pleated sheets and a rich hydrophobic core. The carboxy terminus of ubiquitin is covalently attached to epsilone amino groups of lysines of other proteins. Covalently attached ubiquitin acts as a signal for protolysis.

Ubiquilabel™, created by VLI Research is the most stable labeled human ubiquitin you can buy. VLI has developed gene expression and purification technology that allows for the expression and purification of proteins that are extremely stable during experimental manipulation in NMR machines.

Ubiquilabel™ is a trademark of a variety of labeled human ubiquitins manufactured by VLI Research. For a list of available labeled and unlabeled proteins see our catalog.

View further information on ubiquitin:

• Ubiquitin properties and analysis
• Ubiquitin structure model
• Ubiquitin chemical shifts
• Ubiquitin certificate of analysis
• Selected ubiquitin references